Decreased inducibility of TNF expression in lipid-loaded macrophages

  title={Decreased inducibility of TNF expression in lipid-loaded macrophages},
  author={Mikko P. S. Ares and Maria M Stollenwerk and Anneli Olsson and Bengt Kallin and Stefan Jovinge and Jan Nilsson},
  journal={BMC Immunology},
  pages={13 - 13}
Inflammation and immune responses are considered to be very important in the pathogenesis of atherosclerosis. Lipid accumulation in macrophages of the arterial intima is a characteristic feature of atherosclerosis which can influence the inflammatory potential of macrophages. We studied the effects of lipid loading on the regulation of TNF expression in human monocyte-derived macrophages. In macrophages incubated with acetylated low density lipoprotein (ac-LDL) for 2 days, mRNA expression of… CONTINUE READING
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