Decreased incorporation of glucose into lipids and increased lactate production by adipose tissue after long-term treatment of rats with D-fenfluramine.

@article{alSieni1989DecreasedIO,
  title={Decreased incorporation of glucose into lipids and increased lactate production by adipose tissue after long-term treatment of rats with D-fenfluramine.},
  author={A. al-Sieni and C. Plested and Yves Rolland and D. Brindley},
  journal={Biochemical pharmacology},
  year={1989},
  volume={38 21},
  pages={
          3661-7
        }
}
  • A. al-Sieni, C. Plested, +1 author D. Brindley
  • Published 1989
  • Biology, Medicine
  • Biochemical pharmacology
  • Male rats were treated with ten daily doses of 10 mg of D-fenfluramine/kg. Body weight decreased after days 1 and 2, but thereafter the weight gain paralleled that of the control rats. After the tenth injection there were decreases in the weights of the epididymal fat pads, their fat content, and the average size of the adipocytes after collaginase digestion. The rate of glucose uptake by incubated pieces of adipose tissue was maintained after D-fenfluramine treatment, and the production of… CONTINUE READING
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