Decreased hyperlocomotion induced by MK-801, but not amphetamine and caffeine in mice lacking cellular prion protein (PrP(C)).

Abstract

The cellular prion protein (PrP(C)) has been involved in several neurodegenerative disorders however it has been proposed that it is also be implicated in psychotic disorders. We investigated the effect of three psychotropic drugs in locomotor activity of PrP(C) knockout (Prnp(O/O)) and wild-type mice. The NMDA receptor channel blocker MK-801 (0.25 mg/kg… (More)

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@article{Coitinho2002DecreasedHI, title={Decreased hyperlocomotion induced by MK-801, but not amphetamine and caffeine in mice lacking cellular prion protein (PrP(C)).}, author={Adriana Simon Coitinho and Marcelo de Oliveira Dietrich and Anselmo Hoffmann and Oscar P. Dall'Igna and D M B Oliveira Souza and Vilma Regina Martins and Ricardo Renzo Brentani and Ivan A. Izquierdo and Diogo Rizzato Lara}, journal={Brain research. Molecular brain research}, year={2002}, volume={107 2}, pages={190-4} }