Decreased histone H2B monoubiquitination in malignant gastric carcinoma.

Abstract

AIM To investigate H2B monoubiquitination (uH2B) and H3K4 di- and tri-methylation (H3K4-2me, H3K4-3me) levels and their clinical significance in gastric cancer (GC). METHODS Immunohistochemistry (IGC) was used to detect the differential levels of uH2B, H3K4-2me and H3K4-3me modifications in GC specimens from chemo/radiotherapy-naïve patients who underwent… (More)
DOI: 10.3748/wjg.v19.i44.8099

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