Decreased hippocampal cell proliferation correlates with increased expression of BMP4 in the APPswe/PS1DeltaE9 mouse model of Alzheimer's disease.

@article{Li2008DecreasedHC,
  title={Decreased hippocampal cell proliferation correlates with increased expression of BMP4 in the APPswe/PS1DeltaE9 mouse model of Alzheimer's disease.},
  author={Dongqing Li and Jun Tang and Haiwei Xu and Xiaotang Fan and Yun Bai and Li Yang},
  journal={Hippocampus},
  year={2008},
  volume={18 7},
  pages={
          692-8
        }
}
Alterations in hippocampal cell proliferation have been identified in transgenic (tg) mouse models of Alzheimer's disease (AD); however, relatively little is known about the underlying mechanisms. Previously, we have demonstrated that endogenous level of BMP4 in the dentate gyrus (DG) affects hippocampal cell proliferation in a pentylentetrazol kindling-induced epilepsy model. In the present study, we evaluated hippocampal cell proliferation and BMP4 mRNA level in the APPswe/PS1DeltaE9 tg mouse… CONTINUE READING
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Embryonic Stem Cell in the Therapy of Neurodegenerative Diseases

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Increased BMP6 levels in the brains of Alzheimer's disease patients and APP transgenic mice are accompanied by impaired neurogenesis.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2010
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