Decreased hippocampal NMDA, but not kainate or AMPA receptors in bipolar disorder.

@article{Scarr2003DecreasedHN,
  title={Decreased hippocampal NMDA, but not kainate or AMPA receptors in bipolar disorder.},
  author={Elizabeth Scarr and Geoffrey M Pavey and Suresh Sundram and A U Mackinnon and Brian Dean},
  journal={Bipolar disorders},
  year={2003},
  volume={5 4},
  pages={257-64}
}
OBJECTIVES The purpose of this study was to determine whether there are changes in the density of ionotropic glutamate receptors in the hippocampus of subjects with bipolar disorder. METHODS Using in situ radioligand binding with semiquantitative autoradiography, we measured the density of [3H]MK-801, [3H]CGP39653, [3H]AMPA and [3H]kainate binding in hippocampi, obtained postmortem, from eight subjects with type 1 bipolar disorder and 8 age- and sex-matched controls. RESULTS In subjects… CONTINUE READING

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