Decreased hippocampal 5-HT2A receptor binding in major depressive disorder: in vivo measurement with [18F]altanserin positron emission tomography

  title={Decreased hippocampal 5-HT2A receptor binding in major depressive disorder: in vivo measurement with [18F]altanserin positron emission tomography},
  author={Mark A. Mintun and Yvette I. Sheline and Stephen M. Moerlein and Andrei G. Vlassenko and Yiyun Huang and Abraham Z. Snyder},
  journal={Biological Psychiatry},

Increased 5-HT(2A) receptor binding in euthymic, medication-free patients recovered from depression: a positron emission study with [(11)C]MDL 100,907.

These findings should be considered preliminary but suggest that recovered subjects with a history of recurrent major depression have elevated binding potential of cortical 5-HT(2A) receptors.

Decreased Hippocampal 5-HT2A Receptor Binding in Older Depressed Patients Using [18F]Altanserin Positron Emission Tomography

It may be that prior medication treatment provides a compensatory upregulation of the 5-HT2A receptor, which is associated with the pathophysiology and treatment of major depression.

Decreased brain serotonin 5-HT1A receptor availability in medication-naive patients with major depressive disorder: an in-vivo imaging study using PET and [carbonyl-11C]WAY-100635.

A widespread reduction in the availability of serotonin 5-HT1A receptors was demonstrated in a relatively large sample of drug-naive primary-care patients with MDD, suggesting the involvement of this receptor subtype in the pathophysiology of the illness.

Neuroreceptor imaging in depression

Imaging the serotonin transporter during major depressive disorder and antidepressant treatment.

  • J. Meyer
  • Psychology
    Journal of psychiatry & neuroscience : JPN
  • 2007
5-HTT imaging findings for understanding major depressive disorder and antidepressant treatment will be discussed, and a strong relation between plasma level and occupancy that is not predictable based on affinity alone is discussed.

Reduced serotonin receptors and transporters in normal aging adults: a meta-analysis of PET and SPECT imaging studies

The findings overall identify reduced serotonergic signal transmission in age, which may partially explain differential psychological changes with age, such as why older people use more emotion-focused rather than problem-focused coping strategies.

Different patterns of 5-HT receptor and transporter dysfunction in neuropsychiatric disorders – a comparative analysis of in vivo imaging findings

A retrospective analysis revealed that AD, MDD, BD and SZ differed as to affected brain region, affected synaptic constituent(s) and extent as well as direction of dysfunction in terms of either sensitization or desensitization of transporter and receptor binding sites.

PET studies of the serotonin transporter in the human brain

C-labelled MADAM was shown to be a suitable radioligand for quantitative studies of 5-HTT in the living human brain, and can readily be applied for clinical studies also on small regions such as the raphe nuclei, although pooling of data may be required for bilateral regions to improve accuracy.



Prefrontal cortex 5-HT2 receptors in depression: an [18F]setoperone PET imaging study.

The 5-HT2 binding potential is not increased in untreated depressed subjects who have not made recent suicide attempts, but this negative finding does not rule out the possibility that there is a role for 5- HT2 receptors in treatment or that 5-ht2 receptors are increased in highly suicidal states.

Test–retest variability of serotonin 5‐HT2A receptor binding measured with positron emission tomography and [18F]altanserin in the human brain

Results demonstrate that the test–retest variability of [18F]altanserin‐specific binding is comparable to that of other PET radiotracers and that the regional specific binding of [ 18F]ALTanser in human brain was correlated with the known regional distribution of 5‐HT2A receptors.

Increased 5-Hydroxytryptamine-2 Receptor Binding in the Frontal Cortex of Depressed Patients Responding to Paroxetine Treatment: A Positron Emission Tomography Scan Study

Clinical improvement in patients treated with paroxetine is associated with an increase in the density of 5-HT2A receptors in the frontal cortex, according to positron emission tomography scanning.

Brain serotonin2 receptors in major depression: a positron emission tomography study.

Depressed patients had significantly lower 5-HT(2) receptor binding potential in frontal, temporal, parietal, and occipital cortical regions, according to statistical parametric mapping and region of interest analyses.

Decrease in brain serotonin 2 receptor binding in patients with major depression following desipramine treatment: a positron emission tomography study with fluorine-18-labeled setoperone.

Assessment of the effects of treatment with desipramine hydrochloride on brain 5-HT2 receptors in depressed patients using positron emission tomography (PET) and fluorine-18 (18F)-labeled setoperone showed a significant decrease in 5- HT2 receptor binding, which was observed bilaterally and was particularly prominent in frontal cortex.

Serotonin 5-HT2 receptor imaging in major depression: focal changes in orbito-insular cortex

In depressed patients, [18F]altanserin uptake was significantly reduced in a region of the right hemisphere including the posterolateral orbitofrontal cortex and the anterior insular cortex.

The effect of paroxetine on 5-HT(2A) receptors in depression: an [(18)F]setoperone PET imaging study.

5-HT(2A) receptors down-regulate in young depressed subjects after treatment with paroxetine, but this down-regulation attenuates with age, which suggests that over 6 weeks paroxETine treatment increases 5-HT agonism on 5- HT(2a) receptors in the cortex of young patients with depression.