Decreased hippocampal 5-HT2A receptor binding in major depressive disorder: in vivo measurement with [18F]altanserin positron emission tomography

@article{Mintun2004DecreasedH5,
  title={Decreased hippocampal 5-HT2A receptor binding in major depressive disorder: in vivo measurement with [18F]altanserin positron emission tomography},
  author={Mark A. Mintun and Yvette I. Sheline and Stephen M. Moerlein and Andrei G. Vlassenko and Yiyun Huang and Abraham Z. Snyder},
  journal={Biological Psychiatry},
  year={2004},
  volume={55},
  pages={217-224}
}

Increased 5-HT(2A) receptor binding in euthymic, medication-free patients recovered from depression: a positron emission study with [(11)C]MDL 100,907.

These findings should be considered preliminary but suggest that recovered subjects with a history of recurrent major depression have elevated binding potential of cortical 5-HT(2A) receptors.

Decreased Hippocampal 5-HT2A Receptor Binding in Older Depressed Patients Using [18F]Altanserin Positron Emission Tomography

It may be that prior medication treatment provides a compensatory upregulation of the 5-HT2A receptor, which is associated with the pathophysiology and treatment of major depression.

Decreased brain serotonin 5-HT1A receptor availability in medication-naive patients with major depressive disorder: an in-vivo imaging study using PET and [carbonyl-11C]WAY-100635.

A widespread reduction in the availability of serotonin 5-HT1A receptors was demonstrated in a relatively large sample of drug-naive primary-care patients with MDD, suggesting the involvement of this receptor subtype in the pathophysiology of the illness.

Neuroreceptor imaging in depression

Imaging the serotonin transporter during major depressive disorder and antidepressant treatment.

  • J. Meyer
  • Psychology
    Journal of psychiatry & neuroscience : JPN
  • 2007
5-HTT imaging findings for understanding major depressive disorder and antidepressant treatment will be discussed, and a strong relation between plasma level and occupancy that is not predictable based on affinity alone is discussed.

Reduced serotonin receptors and transporters in normal aging adults: a meta-analysis of PET and SPECT imaging studies

The findings overall identify reduced serotonergic signal transmission in age, which may partially explain differential psychological changes with age, such as why older people use more emotion-focused rather than problem-focused coping strategies.

Different patterns of 5-HT receptor and transporter dysfunction in neuropsychiatric disorders – a comparative analysis of in vivo imaging findings

A retrospective analysis revealed that AD, MDD, BD and SZ differed as to affected brain region, affected synaptic constituent(s) and extent as well as direction of dysfunction in terms of either sensitization or desensitization of transporter and receptor binding sites.

PET studies of the serotonin transporter in the human brain

C-labelled MADAM was shown to be a suitable radioligand for quantitative studies of 5-HTT in the living human brain, and can readily be applied for clinical studies also on small regions such as the raphe nuclei, although pooling of data may be required for bilateral regions to improve accuracy.
...

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