Decreased hippocampal 5-HT2A receptor binding in major depressive disorder: in vivo measurement with [18F]altanserin positron emission tomography

@article{Mintun2004DecreasedH5,
  title={Decreased hippocampal 5-HT2A receptor binding in major depressive disorder: in vivo measurement with [18F]altanserin positron emission tomography},
  author={M. Mintun and Y. Sheline and S. Moerlein and A. Vlassenko and A. Snyder},
  journal={Biological Psychiatry},
  year={2004},
  volume={55},
  pages={217-224}
}
BACKGROUND Serotonin 5-HT(2A) receptors play an important role in the regulation of many functions that are disturbed in patients with major depressive disorder. Postmortem and positron emission tomography studies have reported both increased and decreased 5-HT(2A) receptor binding in different limbic and paralimbic regions. METHODS We conducted a quantitative 5-HT(2A) receptor binding study using positron emission tomography and [(18)F]altanserin of four regions hypothesized to have altered… Expand
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