Decreased hepatic vitamin A after drug administration in men and in rats.

@article{Leo1984DecreasedHV,
  title={Decreased hepatic vitamin A after drug administration in men and in rats.},
  author={Maria Anna Leo and N Lowe and Charles S. Lieber},
  journal={The American journal of clinical nutrition},
  year={1984},
  volume={40 6},
  pages={
          1131-6
        }
}
Eleven patients with moderate drug-induced liver changes were found to have extremely low hepatic vitamin A levels (less than 10% of normal). Their serum vitamin A, retinol-binding protein, and transthyretin were only slightly affected. In rats, two representative drugs (phenobarbital and methylcholanthrene) produced a significant depression of hepatic vitamin A, whereas plasma vitamin A levels remained normal. The livers of drug-treated animals showed no abnormalities except for the expected… 
Drug-induced cytochrome P-450 of rat liver and vitamin a intake
There is evidence in the literature that xenobiotics and, in particular, insecticides, polychlorinated biphenyls, phenobarbital, methycholanthrene, etc., can cause a marked decline in the vitamin A
Effects of ethanol and carbon tetrachloride upon vitamin A status of rats.
TLDR
CCl4 (with phenobarbitol), which is a more potent hepatotoxin as evidenced by a more elevated cytochrome P450 and distorted liver morphology, not only reduced liver vitamin A, but also increased serum vitamin A.
Interaction of drugs and retinol.
Effects of acute ethanol doses or dietary phenobarbitol with carbon tetrachloride exposure on vitamin A status of rats.
TLDR
The results of repeated CCl4/phenobarbital dosings on vitamin A status paralleled, for the most part, the ethanol results, suggesting initial acute exposure of hepatotoxic agents causes metabolic changes that are not fully sustained as the animal adapts to these challenges.
Flupenthixol and cefotiam: effects on vitamin A metabolism in rats
We examined the alterations in vitamin A metabolism as a result of flupenthixol or cefotiam administration. The impact of these drugs on indices of vitamin A status was evaluated in Brown Norway and
Alcohol, liver, and nutrition.
  • C. Lieber
  • Medicine
    Journal of the American College of Nutrition
  • 1991
TLDR
Treatment with vitamin A and other nutritional factors is beneficial but must take into account a narrowed therapeutic window in alcoholics who have increased needs for such nutrients, but also display an enhanced susceptibility to their adverse effects.
Hepatic, metabolic and toxic effects of ethanol: 1991 update.
  • C. Lieber
  • Medicine, Biology
    Alcoholism, clinical and experimental research
  • 1991
Until two decades ago, dietary deficiencies were considered to be the only reason for alcoholics to develop liver disease. As the overall nutrition of the population improved, more emphasis was
ALCOHOL: its metabolism and interaction with nutrients.
  • C. Lieber
  • Medicine, Biology
    Annual review of nutrition
  • 2000
TLDR
PPC opposes major toxic effects of alcohol, with down-regulation of CYP2E1 and reduction of oxidative stress, deactivation of hepatic stellate cells, and increased collagenase activity, which in baboons, results in prevention of ethanol-induced septal fibrosis and cirrhosis.
Alcohol and the liver: metabolism of alcohol and its role in hepatic and extrahepatic diseases.
TLDR
Charles S. Lieber was among the first to use antibiotics for the elimination of gastric bacterial urease and its ammonia production in man, thereby alleviating chronic gastritis and hypoacidity, with attenuation of hepatic encephalopathy in cirrhotics.
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