Decreased gray matter concentration in the insular, orbitofrontal, cingulate, and temporal cortices of cocaine patients.

@article{Franklin2002DecreasedGM,
  title={Decreased gray matter concentration in the insular, orbitofrontal, cingulate, and temporal cortices of cocaine patients.},
  author={Teresa R. Franklin and Paul D. Acton and Joseph A. Maldjian and Jason D. Gray and Jason R Croft and Charles A. Dackis and Charles P O'brien and Anna Rose Childress},
  journal={Biological psychiatry},
  year={2002},
  volume={51 2},
  pages={134-42}
}
BACKGROUND Structural deficiencies within limbic and prefrontal regions may contribute to the characteristic drug-seeking and drug-taking behaviors that prevail in persons dependent on cocaine. To date, a focal structural analysis of the brains of cocaine patients has not been undertaken. METHODS We used voxel based morphometry in conjunction with statistical parametric mapping on the structural magnetic resonance images of cocaine-dependent (n = 13) and cocaine-naive individuals (n = 16) to… CONTINUE READING
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