Decreased glutathione peroxidase activity in mice in response to nafenopin is caused by changes in selenium metabolism.


The activity of selenium-dependent glutathione peroxidase is known to be reduced in the liver of both rats and mice after exposure to nafenopin, as well as other peroxisome proliferators. The mechanism for this down-regulation is not known, but might involve changes in incorporation of selenium into selenoproteins. In this paper we show that both… (More)


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