Decreased glomerulosclerosis in aging by angiotensin-converting enzyme inhibitors.

  title={Decreased glomerulosclerosis in aging by angiotensin-converting enzyme inhibitors.},
  author={Le{\'o}n F. Ferder and Felipe Inserra and Luis Alberto Romano and Liliana Ercole and Viviana Pszenny},
  journal={Journal of the American Society of Nephrology : JASN},
  volume={5 4},
To evaluate the effects of angiotensin-converting enzyme inhibition on renal aging, enalapril was administered in the drinking water to three groups of CF1 mice at doses of 20 mg/L (Group A), 10 mg/L (Group B), and 5 mg/L (Group C). These experimental groups were compared with 20 CF1 mice not receiving enalapril (Group D). At 2 yr, total body weight was 48.1 +/- 7.5 g in Group A, 47.7 +/- 7.1 g in Group B, 47.6 +/- 4.6 g in Group C, and 35.1 +/- 5.4 g in Group D. The ratio of kidney to total… CONTINUE READING
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