Decreased frequency of peripheral CD4(+) CD161(+) Th(17) -precursor cells in kidney transplant recipients on long-term therapy with Belatacept.

@article{Vondran2012DecreasedFO,
  title={Decreased frequency of peripheral CD4(+) CD161(+) Th(17) -precursor cells in kidney transplant recipients on long-term therapy with Belatacept.},
  author={Florian W R Vondran and Kai F Timrott and Sonja Kollrich and J{\"u}rgen Klempnauer and Reinhard Schwinzer and Thomas Becker},
  journal={Transplant international : official journal of the European Society for Organ Transplantation},
  year={2012},
  volume={25 4},
  pages={455-63}
}
Clinical trials have pointed out the promising role of co-stimulation blocker Belatacept for improvement of graft function and avoidance of undesired side-effects associated with calcineurin-inhibitors (CNI). However, due to the worldwide limited availability of appropriate patients, almost no data exist to assess the effects of sustained application of this immunomodulator on the recipient's immune system. The aim of this study was to reveal specific alterations in the composition of… CONTINUE READING

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