Decreased fragile X mental retardation protein expression underlies amygdala dysfunction in carriers of the fragile X premutation.

@article{Hessl2011DecreasedFX,
  title={Decreased fragile X mental retardation protein expression underlies amygdala dysfunction in carriers of the fragile X premutation.},
  author={David Hessl and John M. Wang and Andrea Schneider and Kami Koldewyn and Lien Le and Christine Iwahashi and Katherine Cheung and Flora Tassone and Paul J. Hagerman and Susan M. Rivera},
  journal={Biological psychiatry},
  year={2011},
  volume={70 9},
  pages={859-65}
}
BACKGROUND The fragile X premutation provides a unique opportunity for the study of genetic and brain mechanisms of behavior and cognition in the context of neurodevelopment and neurodegeneration. Although the neurodegenerative phenotype, fragile X-associated tremor/ataxia syndrome, is well described, evidence of a causal link between the premutation and psychiatric disorder earlier in life, clear delineation of a behavioral/cognitive phenotype, and characterization of the physiological basis… CONTINUE READING
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Autism Diagnostic Observation Schedule–WPS Edition

  • C Lord, M Rutter
  • Los Angeles: Western Psychological Services
  • 1989
Highly Influential
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