Decreased expression of the signal-transducing zeta chains in tumor-infiltrating T-cells and NK cells of patients with colorectal carcinoma.

@article{Nakagomi1993DecreasedEO,
  title={Decreased expression of the signal-transducing zeta chains in tumor-infiltrating T-cells and NK cells of patients with colorectal carcinoma.},
  author={Hiroshi Nakagomi and Max Petersson and Inger Magnusson and Claes Juhlin and Morihiro Matsuda and H{\aa}kan Mellstedt and Jean Luc Taupin and Eric Vivier and Paul N. Anderson and Rolf Kiessling},
  journal={Cancer research},
  year={1993},
  volume={53 23},
  pages={5610-2}
}
An impaired immune response is frequently observed in cancer patients and tumor-bearing mice. T-cells from mice with an experimental colon carcinoma were recently shown to express T-cell receptors that completely lacked the signal-transducing molecule CD3 zeta. Here, we have investigated the expression of the signal-transducing molecule zeta on lymphocytes from 14 patients with colorectal carcinomas using flow cytometric analysis of permeabilized cells with a monoclonal antibody (TIA-2; IgG1… CONTINUE READING

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