Decreased expression of the β2 integrin on tumor cells is associated with a reduction in liver metastasis of colorectal cancer in mice

@inproceedings{Benedicto2017DecreasedEO,
  title={Decreased expression of the β2 integrin on tumor cells is associated with a reduction in liver metastasis of colorectal cancer in mice},
  author={Aitor Benedicto and J F Edna M{\'a}rquez and Alba Roura Herrero and Elvira Olaso and Elzbieta Kolaczkowska and Beatriz Arteta},
  booktitle={BMC Cancer},
  year={2017}
}
BackgroundLymphocyte Function-Associated Antigen-1 (LFA-1; CD18/CD11a) is one of the main adhesion molecules used by immune cells to infiltrate the liver under inflammatory conditions. Recently, the expression of this integrin has also been reported on several solid tumors, including colorectal cancer. However, its functional role in the metastatic progression to the liver remains unknown. Using in vitro assays and an experimental orthotopic in vivo model of liver metastasis, we aimed to… CONTINUE READING
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