Decreased expression of myelin gene regulatory factor in Niemann-Pick type C 1 mouse

@article{Yan2011DecreasedEO,
  title={Decreased expression of myelin gene regulatory factor in Niemann-Pick type C 1 mouse},
  author={Xin Yan and Jan Lukas and Martin Witt and Andreas Wree and Rayk H{\"u}bner and Moritz J. Frech and R{\"u}diger K{\"o}hling and Arndt Rolfs and Jiankai Luo},
  journal={Metabolic Brain Disease},
  year={2011},
  volume={26},
  pages={299-306}
}
Niemann-Pick type C 1 (NPC1) disease is an autosomal recessive cholesterol transport defect resulting in a neurodegenerative process in patients mainly at an early age, although some patients may start with manifestation in adult. Since loss of myelin is considered as a main pathogenetic factor, the precise mechanism inducing dysmylination in NPC1 disease is still unclear. In the present study, a quantitative evaluation on the myelin protein and its regulatory factors of oligodendrocytes, such… 

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