Decreased expression of mRNAs encoding non-NMDA glutamate receptors GluR1 and GluR2 in medial temporal lobe neurons in schizophrenia.

@article{Eastwood1995DecreasedEO,
  title={Decreased expression of mRNAs encoding non-NMDA glutamate receptors GluR1 and GluR2 in medial temporal lobe neurons in schizophrenia.},
  author={Sharon L. Eastwood and B Mcdonald and Philip W. J. Burnet and J P Beckwith and Robert W. Kerwin and Paul J. Harrison},
  journal={Brain research. Molecular brain research},
  year={1995},
  volume={29 2},
  pages={211-23}
}
Schizophrenia is associated with a complex pattern of alterations in the glutamatergic system of the brain. Previous studies have shown a reduced density of some hippocampal non-N-methyl-D-aspartate (non-NMDA) receptors which is accompanied by a loss of encoding receptor mRNA. We have extended this work using in situ hybridization histochemistry with… CONTINUE READING