Decreased expression of hepatocyte nuclear factor 4α (Hnf4α)/microRNA-122 (miR-122) axis in hepatitis B virus-associated hepatocellular carcinoma enhances potential oncogenic GALNT10 protein activity.

@article{Wu2014DecreasedEO,
  title={Decreased expression of hepatocyte nuclear factor 4α (Hnf4α)/microRNA-122 (miR-122) axis in hepatitis B virus-associated hepatocellular carcinoma enhances potential oncogenic GALNT10 protein activity.},
  author={Qian Wu and Hai-ou Liu and Yi-dong Liu and Wei-si Liu and Deng Pan and Wei-juan Zhang and Liu Yang and Qiang Fu and Jie-jie Xu and Jian-Xin Gu},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={290 2},
  pages={
          1170-85
        }
}
MicroRNA-122 (miR-122), a mammalian liver-specific miRNA, has been reported to play crucial roles in the control of diverse aspects of hepatic function and dysfunction, including viral infection and hepatocarcinogenesis. In this study, we explored the clinical significance, transcriptional regulation, and direct target of miR-122 in hepatitis B virus (HBV)-associated hepatocellular carcinoma. Reduced expression of miR-122 in patients with HBV-associated hepatocellular carcinoma was correlated… CONTINUE READING

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