Decreased expression of heat shock protein 72 in skeletal muscle of patients with type 2 diabetes correlates with insulin resistance.

@article{Kurucz2002DecreasedEO,
  title={Decreased expression of heat shock protein 72 in skeletal muscle of patients with type 2 diabetes correlates with insulin resistance.},
  author={Istv{\'a}n Kurucz and Agota Morva and Allan Vaag and K. Eriksson and Xudong Huang and Leif Groop and L{\'a}szl{\'o} Kor{\'a}nyi},
  journal={Diabetes},
  year={2002},
  volume={51 4},
  pages={1102-9}
}
Oxidative stress has been ascribed a role in the pathogenesis of diabetes and its complications, and stress proteins have been shown to protect organisms in vitro and in vivo against oxidative stress. To study the putative role of one of the most abundant cytoprotective stress proteins, inducible cytoplasmic 72-kDa-mass heat shock protein (Hsp-72), in the pathogenesis of diabetes, we measured its mRNA concentration in muscle biopsies from six type 2 diabetic patients and six healthy control… CONTINUE READING
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