Decreased expression of gastrokine 1 and the trefoil factor interacting protein TFIZ1/GKN2 in gastric cancer: influence of tumor histology and relationship to prognosis.

@article{Moss2008DecreasedEO,
  title={Decreased expression of gastrokine 1 and the trefoil factor interacting protein TFIZ1/GKN2 in gastric cancer: influence of tumor histology and relationship to prognosis.},
  author={Steven F. Moss and Jin-Woo Lee and Edmond Sabo and Anna K Rubin and John J Rommel and Bruce R. Westley and Felicity E. B. May and John Gao and Patricia A. Meitner and Rose Tavares and Murray B. Resnick},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2008},
  volume={14 13},
  pages={4161-7}
}
PURPOSE Transcriptional profiling showed decreased expression of gastrokine 1 (GKN1) and the related trefoil factor interacting protein (TFIZ1/GKN2) in Helicobacter pylori infection. Decreased GKN1 and GKN2 mRNA expression has been reported in gastric adenocarcinoma. We have examined GKN1 and GKN2 protein expression in a large gastric cancer series, correlated expression with tumor subtype, and evaluated their utility as prognostic biomarkers. EXPERIMENTAL DESIGN GKN1, GKN2, and the trefoil… CONTINUE READING

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