Decreased expression of eukaryotic initiation factor 3f deregulates translation and apoptosis in tumor cells

@article{Shi2006DecreasedEO,
  title={Decreased expression of eukaryotic initiation factor 3f deregulates translation and apoptosis in tumor cells},
  author={Jingxue Shi and Amber Christine Kahle and John W. B. Hershey and Barbara M Honchak and James A. Warneke and Stanley P. L. Leong and Mark A. Nelson},
  journal={Oncogene},
  year={2006},
  volume={25},
  pages={4923-4936}
}
The eukaryotic initiation factor 3f (eIF3f) is the p47 subunit of the multi-subunit eIF3 complex. eIF3 plays an important role in translation initiation. In the present study, we investigate the biological function of eIF3f in translation and apoptosis in tumor cells. We demonstrated for the first time that eIF3f is downregulated in most human tumors using a cancer profiling array and confirmed by real-time reverse transcription PCR in melanoma and pancreatic cancer. Overexpression of eIF3f… CONTINUE READING

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