Decreased expression of eosinophil peroxidase and major basic protein messenger RNAs during eosinophil maturation.

@article{Gruart1992DecreasedEO,
  title={Decreased expression of eosinophil peroxidase and major basic protein messenger RNAs during eosinophil maturation.},
  author={V Gruart and M J Truong and Jo{\"e}l Plumas and Marc Zandecki and J. P. Kusnierz and Lionel Prin and Denis Vinatier and Arnaud Capron and Micka{\"e}l Capron},
  journal={Blood},
  year={1992},
  volume={79 10},
  pages={2592-7}
}
We evaluated the levels of mRNAs encoding cationic proteins in peripheral blood eosinophils (PBE) purified from patients with eosinophilia and in eosinophils differentiated from cord blood cells (CBC) by culture with recombinant human interleukin-3 (rhIL-3), rhGM-CSF, and rhIL-5. Messenger RNAs encoding eosinophil peroxidase (EPO), major basic protein (MBP), eosinophil-derived neurotoxin (EDN), and eosinophil cationic protein (ECP) were detected by Northern blot hybridization with the… CONTINUE READING