Decreased expression of decay-accelerating factor on endothelial cells of immune complex-mediated vasculitic skin lesions.


Endothelial cells may be damaged directly by the membrane attack complex of complement in immune complex vasculitis of the skin. However, for endothelial cell membrane injury to occur, normal regulatory mechanisms must fail. One of the main complement regulatory proteins of endothelial cells is decay-accelerating factor, a surface protein which interferes… (More)


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