Decreased expression of CD3zeta and nuclear transcription factor kappa B in patients with pulmonary tuberculosis: potential mechanisms and reversibility with treatment.

@article{Zea2006DecreasedEO,
  title={Decreased expression of CD3zeta and nuclear transcription factor kappa B in patients with pulmonary tuberculosis: potential mechanisms and reversibility with treatment.},
  author={Arnold H. Zea and Kirk S. Culotta and Juzar Ali and Carol I. Mason and Hae-Joon Park and Jovanny Zabaleta and Luis Fernando Garc{\'i}a and Augusto Ochoa},
  journal={The Journal of infectious diseases},
  year={2006},
  volume={194 10},
  pages={1385-93}
}
BACKGROUND The protective immune response against Mycobacterium tuberculosis relies both on antigen-presenting cells and on T lymphocytes. In patients with different forms of tuberculosis, varying degrees of T cell function--ranging from positive delayed-type hypersensitivity, in asymptomatic infected healthy individuals, to the absence of the response, in patients with miliary or pulmonary tuberculosis (PTB)--have been reported. The decreased expression of CD3zeta reported in T cells from… CONTINUE READING

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