Decreased expression of CD200R3 on mouse basophils as a novel marker for IgG1-mediated anaphylaxis

@inproceedings{Iwamoto2015DecreasedEO,
  title={Decreased expression of CD200R3 on mouse basophils as a novel marker for IgG1-mediated anaphylaxis},
  author={Hiroshi Iwamoto and Takeshi Matsubara and Yuki Nakazato and Kazuyoshi Namba and Yasuhiro Takeda},
  booktitle={Immunity, inflammation and disease},
  year={2015}
}
IgE-mediated mast cell activation is the trigger of anaphylaxis in humans, whereas it is known that not only IgE but also IgG can induce anaphylaxis in mice. In our preliminary experiments, the expression of a murine basophil identification marker, CD200R3, on antigen-sensitized basophils decreased following specific antigen challenge. Interestingly, this decrease did not always correspond with increased expression of the IgE-mediated basophil activation marker CD200R1. Since IgG as well as IgE… CONTINUE READING

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