Decreased ethanol sensitivity and tolerance development in gamma-protein kinase C null mutant mice is dependent on genetic background.

@article{Bowers1999DecreasedES,
  title={Decreased ethanol sensitivity and tolerance development in gamma-protein kinase C null mutant mice is dependent on genetic background.},
  author={Barbara J. Bowers and E H Owen and Allan C. Collins and Asa Abeliovich and Susumu Tonegawa and Jeanne M. Wehner},
  journal={Alcoholism, clinical and experimental research},
  year={1999},
  volume={23 3},
  pages={387-97}
}
Initial sensitivity and tolerance development to the sedative-hypnotic and hypothermic effects of ethanol were investigated in gamma-protein kinase C (PKC) null mutant mice. Null mutants from a C57BL/6J x 129/SvJ mixed genetic background demonstrated decreased ethanol sensitivity and failed to develop chronic tolerance after 10 days of ethanol liquid diet. However, when the null mutation was introgressed onto a C57BL/6J background for six generations, the "no tolerance" phenotype for sedative… CONTINUE READING

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