Decreased endothelium-dependent vasoconstriction to noradrenaline in acute-stressed rats is potentiated by previous chronic stress: nitric oxide involvement.

@article{Cordellini1998DecreasedEV,
  title={Decreased endothelium-dependent vasoconstriction to noradrenaline in acute-stressed rats is potentiated by previous chronic stress: nitric oxide involvement.},
  author={Sandra Cordellini and V S Vassilieff},
  journal={General pharmacology},
  year={1998},
  volume={30 1},
  pages={79-83}
}
1. The objective was to determine whether nitric oxide participates in stress adaptive responses. Acute stress (AS) decreased endothelium-dependent vasoconstriction to noradrenaline (NA) in rat aorta [control rat (CR) 3.90 +/- 0.18, n = 22; AS 2.76 +/- 0.20, n = 13; P < 0.05]. 2. Chronic stress exposure previous to AS (CS) potentiated this effect [CS 1.93 +/- 0.19; n = 9; P < 0.05 related to CR, P < 0.05 related to AS]. 3. Methylene blue and NG-monomethyl-L-arginine, but not indomethacin… CONTINUE READING