Decreased endogenous levels of Ac-SDKP promote organ fibrosis.

@article{Cavasin2007DecreasedEL,
  title={Decreased endogenous levels of Ac-SDKP promote organ fibrosis.},
  author={Maria A. Cavasin and Tang-dong Liao and Xiao-Ping Yang and James J. Yang and Oscar A. Carretero},
  journal={Hypertension},
  year={2007},
  volume={50 1},
  pages={130-6}
}
There is convincing evidence that chronic treatment with N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP), a peptide normally found in tissues and biological fluids, reduces collagen deposition in the heart and kidneys of hypertensive rats and rats with myocardial infarction. However, it is not known whether endogenous Ac-SDKP at basal concentrations has any physiological function related to collagen deposition. Prolyl oligopeptidase is responsible for release of Ac-SDKP from its precursor… CONTINUE READING

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Prolyl oligopep - tidase is involved in release of the antifibrotic peptide Ac - SDKP

  • MA Cavasin, Rhaleb N-E, Yang X-P, OA Carretero
  • Hypertension
  • 2004

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