Decreased endocannabinoid levels in the brain and beneficial effects of agents activating cannabinoid and/or vanilloid receptors in a rat model of multiple sclerosis.

@article{Cabranes2005DecreasedEL,
  title={Decreased endocannabinoid levels in the brain and beneficial effects of agents activating cannabinoid and/or vanilloid receptors in a rat model of multiple sclerosis.},
  author={Ana Cabranes and Katerina Venderova and Eva de Lago and Filomena Fezza and Antonio Arag{\'o}n S{\'a}nchez and Leyre Mestre and Marta Valenti and Antonio Garc{\'i}a-Merino and Jos{\'e} Antonio Vera Ramos and Vincenzo Di Marzo and Javier Fern{\'a}ndez-Ruiz},
  journal={Neurobiology of disease},
  year={2005},
  volume={20 2},
  pages={207-17}
}
Recent studies have addressed the changes in endocannabinoid ligands and receptors that occur in multiple sclerosis, as a way to explain the efficacy of cannabinoid compounds to alleviate spasticity, pain, tremor, and other signs of this autoimmune disease. Using Lewis rats with experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis, we recently found a decrease in cannabinoid CB1 receptors mainly circumscribed to the basal ganglia, which could be related to the… CONTINUE READING
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