Decreased dopamine D2 receptor availability is associated with reduced frontal metabolism in cocaine abusers

  title={Decreased dopamine D2 receptor availability is associated with reduced frontal metabolism in cocaine abusers},
  author={N. Volkow and J. Fowler and G. Wang and R. Hitzemann and J. Logan and D. Schlyer and S. Dewey and A. Wolf},
  • N. Volkow, J. Fowler, +5 authors A. Wolf
  • Published 1993
  • Psychology, Medicine
  • Synapse
  • Decreased dopaminergic function has been postulated to underlie cocaine addiction. To examine the possibility that dysfunction of brain regions subserved by the dopamine system could promote cocaine self‐administration, positron emission tomography and a dual‐tracer approach was used to examine dopamine D2 receptor availability and regional brain glucose metabolism in cocaine abusers. When compared to normal controls, cocaine abusers showed significant decreases in dopamine D2 receptor… CONTINUE READING
    850 Citations
    PET imaging of dopamine D2 receptors during chronic cocaine self-administration in monkeys
    • 412
    • PDF
    Increased vulnerability to cocaine in mice lacking dopamine D3 receptors
    • 55
    • PDF
    Striatal dopamine D2 receptor availability predicts the thalamic and medial prefrontal responses to reward in cocaine abusers three years later
    • 50
    • PDF
    Kappa-Opioid Receptor Signaling in the Striatum as a Potential Modulator of Dopamine Transmission in Cocaine Dependence
    • 21
    • PDF
    Cocaine Dependence and D2 Receptor Availability in the Functional Subdivisions of the Striatum: Relationship with Cocaine-Seeking Behavior
    • 250
    • Highly Influenced
    • PDF
    Serotonin 5-HT2 receptor availability in chronic cocaine abusers.
    • 11


    Effects of chronic cocaine abuse on postsynaptic dopamine receptors.
    • 370
    Changes in brain glucose metabolism in cocaine dependence and withdrawal.
    • 421
    New concepts in cocaine addiction: The dopamine depletion hypothesis
    • 557
    Neurobiology of cocaine abuse.
    • 344
    Cortical dopaminergic involvement in cocaine reinforcement.
    • 496
    Age-dependent decline in human brain dopamine D1 and D2 receptors
    • 185