Decreased dopamine D2 receptor availability is associated with reduced frontal metabolism in cocaine abusers

@article{Volkow1993DecreasedDD,
  title={Decreased dopamine D2 receptor availability is associated with reduced frontal metabolism in cocaine abusers},
  author={N. Volkow and J. Fowler and G. Wang and R. Hitzemann and J. Logan and D. Schlyer and S. Dewey and A. Wolf},
  journal={Synapse},
  year={1993},
  volume={14}
}
  • N. Volkow, J. Fowler, +5 authors A. Wolf
  • Published 1993
  • Psychology, Medicine
  • Synapse
  • Decreased dopaminergic function has been postulated to underlie cocaine addiction. To examine the possibility that dysfunction of brain regions subserved by the dopamine system could promote cocaine self‐administration, positron emission tomography and a dual‐tracer approach was used to examine dopamine D2 receptor availability and regional brain glucose metabolism in cocaine abusers. When compared to normal controls, cocaine abusers showed significant decreases in dopamine D2 receptor… CONTINUE READING
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