Decreased dopamine D2/D3-receptor binding in temporal lobe epilepsy: an [18F]fallypride PET study.

@article{Werhahn2006DecreasedDD,
  title={Decreased dopamine D2/D3-receptor binding in temporal lobe epilepsy: an [18F]fallypride PET study.},
  author={Konrad J. Werhahn and Christian Landvogt and Sven Klimpe and Hans-Georg Buchholz and Igor Yakushev and Thomas Siessmeier and Wibke S M{\"u}ller-Forell and Markus Piel and Frank R{\"o}sch and Martin Glaser and Mathias Schreckenberger and Peter Bartenstein},
  journal={Epilepsia},
  year={2006},
  volume={47 8},
  pages={1392-6}
}
PURPOSE Although animal data are suggestive, evidence for an alteration of the extrastriatal dopaminergic system in human focal epilepsy is missing. METHODS To quantify D2/D3-receptor density, we studied seven patients with temporal lobe epilepsy (TLE) and nine age-matched controls with positron emission tomography (PET) by using the high-affinity dopamine D2/D3-receptor ligand [18F]Fallypride ([18F]FP) suitable for imaging extrastriatal binding. TLE was defined by interictal and ictal video… CONTINUE READING