Decreased dissolution of ZnO by iron doping yields nanoparticles with reduced toxicity in the rodent lung and zebrafish embryos.

@article{Xia2011DecreasedDO,
  title={Decreased dissolution of ZnO by iron doping yields nanoparticles with reduced toxicity in the rodent lung and zebrafish embryos.},
  author={Tian Xia and Yan Zhao and Tina M. Sager and Saji George and Suman Pokhrel and Ning Li and David A. Schoenfeld and Huan Meng and Sijie Lin and Xiang Wang and Meiying Wang and Zhaoxia Ji and Jeffrey I. Zink and Lutz M{\"a}dler and Vincent Castranova and Shuo Lin and Andre E. Nel},
  journal={ACS nano},
  year={2011},
  volume={5 2},
  pages={
          1223-35
        }
}
We have recently shown that the dissolution of ZnO nanoparticles and Zn(2+) shedding leads to a series of sublethal and lethal toxicological responses at the cellular level that can be alleviated by iron doping. Iron doping changes the particle matrix and slows the rate of particle dissolution. To determine whether iron doping of ZnO also leads to lesser toxic effects in vivo, toxicity studies were performed in rodent and zebrafish models. First, we synthesized a fresh batch of ZnO… 

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