Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia.

  title={Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia.},
  author={Leisa A. Glantz and David A. Lewis},
  journal={Archives of general psychiatry},
  volume={57 1},
BACKGROUND The pathophysiological characteristics of schizophrenia appear to involve altered synaptic connectivity in the dorsolateral prefrontal cortex. Given the central role that layer 3 pyramidal neurons play in corticocortical and thalamocortical connectivity, we hypothesized that the excitatory inputs to these neurons are altered in subjects with schizophrenia. METHODS To test this hypothesis, we determined the density of dendritic spines, markers of excitatory inputs, on the basilar… CONTINUE READING
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A subclass of prefrontal g-aminobutyric acid axon terminals are selectively altered in schizophrenia

  • Woo T-U, RE Whitehead, DS Melchitzky, DA Lewis
  • Proc Natl Acad Sci U S A
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Decreased expression of GAD67 mRNA in a subpopulation of GABA neurons in the prefrontal cortex of schizophrenic subjects

  • DW Volk, MC Austin, DA. Lewis
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