Decreased cortical muscarinic M1 receptors in schizophrenia are associated with changes in gene promoter methylation, mRNA and gene targeting microRNA

@inproceedings{Scarr2013DecreasedCM,
  title={Decreased cortical muscarinic M1 receptors in schizophrenia are associated with changes in gene promoter methylation, mRNA and gene targeting microRNA},
  author={Elizabeth Scarr and Jeffrey M Craig and Murray J. Cairns and Myoung Suk Seo and John C. Galati and Natalie Jane Beveridge and Andrew S. Gibbons and Susan Juzva and Barbara Weinrich and Mandy Parkinson-Bates and Adam P. Carroll and Richard Saffery and Brian Dean},
  booktitle={Translational Psychiatry},
  year={2013}
}
Many studies have shown decreased cortical muscarinic M1 receptors (CHRM1) in schizophrenia (Sz), with one study showing Sz can be separated into two populations based on a marked loss of CHRM1 (∼75%) in ∼25% of people (Def-Sz) with the disorder. To better understand the mechanism contributing to the loss of CHRM1 in Def-Sz, we measured specific markers of gene expression in the cortex of people with Sz as a whole, people differentiated into Def-Sz and people with Sz that do not have a deficit… CONTINUE READING
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