Decreased concentrations of prostate-specific antigen and human glandular kallikrein 2 in malignant versus nonmalignant prostatic tissue.

@article{Magklara2000DecreasedCO,
  title={Decreased concentrations of prostate-specific antigen and human glandular kallikrein 2 in malignant versus nonmalignant prostatic tissue.},
  author={Angeliki Magklara and Andreas Scorilas and Carsten Stephan and Glen O Kristiansen and Steffen Hauptmann and Klaus Jung and Eleftherios P Diamandis},
  journal={Urology},
  year={2000},
  volume={56 3},
  pages={527-32}
}
OBJECTIVES To study quantitatively the relative expression of human glandular kallikrein 2 (hK2) and prostate-specific antigen (PSA) in paired (from the same patient) cancerous and noncancerous prostatic tissue to evaluate whether these proteins are overexpressed or underexpressed in cancer. METHODS We studied 14 patients who underwent radical retropubic prostatectomy for prostate cancer. Cancerous and adjacent normal tissues were excised and then extracted to prepare cytosolic extracts. The… CONTINUE READING