Decreased colonization of fecal Clostridium coccoides/Eubacterium rectale species from ulcerative colitis patients in an in vitro dynamic gut model with mucin environment.

@article{Vermeiren2012DecreasedCO,
  title={Decreased colonization of fecal Clostridium coccoides/Eubacterium rectale species from ulcerative colitis patients in an in vitro dynamic gut model with mucin environment.},
  author={Joan Vermeiren and Pieter van den Abbeele and Debby Laukens and Louise Kristine Vigsnaes and M De Vos and Nico Boon and Tom Richard Van de Wiele},
  journal={FEMS microbiology ecology},
  year={2012},
  volume={79 3},
  pages={685-96}
}
The mucus layer in the colon, acting as a barrier to prevent invasion of pathogens, is thinner and discontinuous in patients with ulcerative colitis (UC). A recent developed in vitro dynamic gut model, the M-SHIME, was used to compare long-term colonization of the mucin layer by the microbiota from six healthy volunteers (HV) and six UC patients and thus distinguish the mucin adhered from the luminal microbiota. Although under the same nutritional conditions, short-chain fatty acid production… CONTINUE READING
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