Decreased clearance of serum retinol-binding protein and elevated levels of transthyretin in insulin-resistant ob/ob mice.

@article{Mody2008DecreasedCO,
  title={Decreased clearance of serum retinol-binding protein and elevated levels of transthyretin in insulin-resistant ob/ob mice.},
  author={Nimesh Mody and Timothy E. Graham and Yuki Tsuji and Qin Yang and Barbara B. Kahn},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2008},
  volume={294 4},
  pages={E785-93}
}
Serum retinol-binding protein (RBP4) is secreted by liver and adipocytes and is implicated in systemic insulin resistance in rodents and humans. RBP4 normally binds to the larger transthyretin (TTR) homotetramer, forming a protein complex that reduces renal clearance of RBP4. To determine whether alterations in RBP4-TTR binding contribute to elevated plasma RBP4 levels in insulin-resistant states, we investigated RBP4-TTR interactions in leptin-deficient ob/ob mice and high-fat-fed obese mice… CONTINUE READING

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