Decreased cholesterol levels reflect a consumption of anti-inflammatory isoprenoids associated with an impaired control of inflammation in a mouse model of mevalonate kinase deficiency

@article{Marcuzzi2010DecreasedCL,
  title={Decreased cholesterol levels reflect a consumption of anti-inflammatory isoprenoids associated with an impaired control of inflammation in a mouse model of mevalonate kinase deficiency},
  author={Annalisa Marcuzzi and Giuliana Decorti and Alessandra Pontillo and Alessandro Ventura and Alberto Tommasini},
  journal={Inflammation Research},
  year={2010},
  volume={59},
  pages={335-338}
}
The aim of this study was to evaluate, in a mouse model of mevalonate kinase deficiency (MKD), the possible link between inflammatory symptoms and serum cholesterol levels. Balb/c mice were treated with alendronate and bacterial muramyl dipeptide. Body temperature, interleukin-1β (IL-1β) secretion and serum cholesterol levels were measured. An increased production of the pro-inflammatory cytokine IL-1β (p < 0.05) and a rise in body temperature (p < 0.05) was observed, while, in parallel, serum… CONTINUE READING
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