Decreased cerebral catabolism of [3H]histamine in vivo after S-adenosylmethionine administration.

Abstract

Administration of S-adenosyl-L-methionine (SAM) (200 mg/kg) to adult mice significantly elevated its cerebral levels while the steady-state levels of histamine (HA) and S-adenosyl-L-homocysteine remained unaltered. [3H]HA (1 microCi/10 microliters) was injected intraventricularly (i.vt.) 20 sec, 2, 5, 10 or 20 min prior to sacrifice (1 hr after SAM) and… (More)

Topics

Cite this paper

@article{Schatz1981DecreasedCC, title={Decreased cerebral catabolism of [3H]histamine in vivo after S-adenosylmethionine administration.}, author={Robert A. Schatz and Giorgio Stramentinoli and Otto Z. Sellinger}, journal={The Journal of pharmacology and experimental therapeutics}, year={1981}, volume={216 1}, pages={118-24} }