Decreased cerebral blood flow during acute hyperglycemia.

  title={Decreased cerebral blood flow during acute hyperglycemia.},
  author={Robert B. Duckrow},
  journal={Brain research},
  volume={703 1-2},
Cerebral blood flow (CBF) decreases during acute hyperglycemia but the mechanism of this change is unknown. The role that plasma osmolality plays in this effect was reexamined in pentobarbital-anesthetized rats using a continuous measure of CBF, laser-Doppler flowmetry. CBF decreased 25% during acute elevation of plasma osmolality induced by intraperitoneal injection of concentrated solutions of glucose or mannitol. In addition there were brief transient increases of CBF with peak magnitude 2-4… CONTINUE READING


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