Decreased cell proliferation and altered cytokine production in frail older adults.

@article{Leng2004DecreasedCP,
  title={Decreased cell proliferation and altered cytokine production in frail older adults.},
  author={Sean X. Leng and Huanle Yang and Jeremy D. Walston},
  journal={Aging clinical and experimental research},
  year={2004},
  volume={16 3},
  pages={249-52}
}
BACKGROUND AND AIMS Frailty is a geriatric syndrome that predicts increased morbidity and mortality. In order to investigate specific immune system modulations that may contribute to frailty, eleven age- and sex-matched pairs of community-dwelling frail and non-frail older adults were identified. METHODS Peripheral blood mononuclear cells (PBMC) were isolated and PBMC proliferation and production of IL-6, tumor necrosis factor (TNF)-alpha, and IL-10 in the presence and absence of… CONTINUE READING

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