Decreased cardiac output at the onset of diabetes: renal mechanisms and peripheral vasoconstriction.

@article{Brands2000DecreasedCO,
  title={Decreased cardiac output at the onset of diabetes: renal mechanisms and peripheral vasoconstriction.},
  author={Michael W. Brands and Sharyn M. Fitzgerald and W H Hewitt and A E Hailman},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2000},
  volume={278 5},
  pages={E917-24}
}
Recently we reported that hindquarter blood flow, measured 24 h/day, decreased progressively over the first 6 days of type 1 diabetes in rats. That response, coupled with the tendency of mean arterial pressure to increase, suggested a vasoconstrictor response. The purpose of this study was to measure the changes in cardiac output together with the renal hemodynamic and excretory responses to allow integrative determination of whether vasoconstriction likely accompanies the onset of type 1… CONTINUE READING

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The purpose of this study was to measure the changes in cardiac output together with the renal hemodynamic and excretory responses to allow integrative determination of whether vasoconstriction likely accompanies the onset of type 1 diabetes .
The purpose of this study was to measure the changes in cardiac output together with the renal hemodynamic and excretory responses to allow integrative determination of whether vasoconstriction likely accompanies the onset of type 1 diabetes .
Decreased cardiac output at the onset of diabetes : renal mechanisms and peripheral vasoconstriction .
Decreased cardiac output at the onset of diabetes : renal mechanisms and peripheral vasoconstriction .
The purpose of this study was to measure the changes in cardiac output together with the renal hemodynamic and excretory responses to allow integrative determination of whether vasoconstriction likely accompanies the onset of type 1 diabetes .
This was associated with significant increases in glomerular filtration rate , renal blood flow , and microalbuminuria as well as urinary fluid and sodium losses , with a negative cumulative sodium balance averaging 15.7 + /-
This was associated with significant increases in glomerular filtration rate , renal blood flow , and microalbuminuria as well as urinary fluid and sodium losses , with a negative cumulative sodium balance averaging 15.7 + /-
The purpose of this study was to measure the changes in cardiac output together with the renal hemodynamic and excretory responses to allow integrative determination of whether vasoconstriction likely accompanies the onset of type 1 diabetes .
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