Decreased cardiac beta-adrenoceptors in hypertensive rats.

Abstract

1. beta-Adrenoceptors have been investigated in cardiac and renal cell membranes from hypertensive and normal rats. 2. The 125I-labelled beta-adrenoceptor antagonist 1-(4-iodophenoxy)-3-isopropylaminopropan-2-ol was used to measure directly the number and affinity of receptors. 3. Cardiac membranes from hypertensive rats had a lower concentration of beta… (More)

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