Decreased calcium-sensing receptor expression in hyperplastic parathyroid glands of uremic rats: role of dietary phosphate.

@article{Brown1999DecreasedCR,
  title={Decreased calcium-sensing receptor expression in hyperplastic parathyroid glands of uremic rats: role of dietary phosphate.},
  author={Alex J. Brown and Cynthia S. Ritter and Jane L. Finch and Eduardo A. Slatopolsky},
  journal={Kidney international},
  year={1999},
  volume={55 4},
  pages={
          1284-92
        }
}
BACKGROUND The abnormal control of parathyroid hormone secretion in chronic renal failure is attributed, in part, to down-regulation of the calcium-sensing receptor (CaR) in hyperplastic parathyroid tissue. The cause of this down-regulation is unknown. Here we examined the roles of uremia and parathyroid hyperplasia on parathyroid gland (PTG) CaR expression in the rat model of renal failure. METHODS Rats made uremic by 5/6 nephrectomy were maintained for one month on diets containing 0.2% P… CONTINUE READING
Highly Cited
This paper has 89 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 51 extracted citations

Acute regulation of parathyroid hormone by dietary phosphate.

American journal of physiology. Endocrinology and metabolism • 2005
View 9 Excerpts
Method Support
Highly Influenced

Calcium in Internal Medicine

Hirotoshi Morii, Yoshiki Nishizawa, K. Morii, Toshiko Nishizawa, Meira Massry
Springer London • 2002
View 6 Excerpts
Highly Influenced

Glandular regulation of interstitial diffusion: a model and simulation of a novel physiological mechanism.

American journal of physiology. Endocrinology and metabolism • 2002
View 6 Excerpts
Highly Influenced

The calcium-sensing receptor in human disease.

Frontiers in bioscience : a journal and virtual library • 2003
View 14 Excerpts
Highly Influenced

90 Citations

0510'00'04'09'14'19
Citations per Year
Semantic Scholar estimates that this publication has 90 citations based on the available data.

See our FAQ for additional information.