Decreased calcium channel currents and facilitated epinephrine release in the Ca2+ channel beta3 subunit-null mice.

The beta subunits of voltage-dependent calcium channels are known to modify calcium channel currents through pore-forming alpha1 subunits. The beta3 subunit is expressed in the adrenal gland and participates in forming various calcium channel types. We performed a series of experiments in beta3-null mice to determine the role of the beta3 subunit in… CONTINUE READING