Decreased brown fat markedly enhances susceptibility to diet-induced obesity, diabetes, and hyperlipidemia.

@article{Hamann1996DecreasedBF,
  title={Decreased brown fat markedly enhances susceptibility to diet-induced obesity, diabetes, and hyperlipidemia.},
  author={Andreas Hamann and Jeffrey S. Flier and Bradford B. Lowell},
  journal={Endocrinology},
  year={1996},
  volume={137 1},
  pages={
          21-9
        }
}
Previous studies have indicated that rodents are relatively resistant to diet-induced obesity and that this resistance may be mediated in part by the capacity for diet-induced thermogenesis in brown adipose tissue (BAT). To test this hypothesis, we fed UCP-DTA transgenic with toxigene-mediated ablation of BAT and their control littermates a "Western diet" [21% (wt/wt) fat] or normal mouse chow [6.5% (wt/wt) fat]. The diets were begun at weaning (19 days old). At the age of 12 weeks, transgenic… CONTINUE READING
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