Decreased brain dopamine cell numbers in human cocaine users

  title={Decreased brain dopamine cell numbers in human cocaine users},
  author={K. Little and Eric Ramssen and Ryan Welchko and Vitaly Volberg and B. Cassin},
  journal={Psychiatry Research},
  • K. Little, Eric Ramssen, +2 authors B. Cassin
  • Published 2009
  • Medicine
  • Psychiatry Research
  • Cocaine use diminishes striatal and midbrain dopamine neuronal components in both post-mortem and in vivo human experiments. The diffuse nature of these declines suggests the possibility that cocaine use might cause a loss of dopamine neurons in humans. Previous rodent studies have not detected cocaine-induced dopamine cell damage. The present experiment involved counting midbrain dopamine neurons utilizing both melanin and tyrosine hydroxylase immunoreactivity. Well-preserved blocks ranging… CONTINUE READING
    74 Citations
    Cocaine-mediated downregulation of microglial miR-124 expression involves promoter DNA methylation
    • 14
    Structural plasticity in mesencephalic dopaminergic neurons produced by drugs of abuse: critical role of BDNF and dopamine
    • 40
    • PDF


    Striatal dopaminergic abnormalities in human cocaine users.
    • 112
    Brain dopamine transporter messenger RNA and binding sites in cocaine users: a postmortem study.
    • 80
    • PDF
    Loss of striatal vesicular monoamine transporter protein (VMAT2) in human cocaine users.
    • 76
    Dopamine transport function is elevated in cocaine users
    • 146
    Cocaine Uptake Is Decreased in the Brain of Detoxified Cocaine Abusers
    • 112
    • PDF