Decreased brain dopamine cell numbers in human cocaine users
@article{Little2009DecreasedBD, title={Decreased brain dopamine cell numbers in human cocaine users}, author={K. Little and Eric Ramssen and Ryan Welchko and Vitaly Volberg and B. Cassin}, journal={Psychiatry Research}, year={2009}, volume={168}, pages={173-180} }
Cocaine use diminishes striatal and midbrain dopamine neuronal components in both post-mortem and in vivo human experiments. The diffuse nature of these declines suggests the possibility that cocaine use might cause a loss of dopamine neurons in humans. Previous rodent studies have not detected cocaine-induced dopamine cell damage. The present experiment involved counting midbrain dopamine neurons utilizing both melanin and tyrosine hydroxylase immunoreactivity. Well-preserved blocks ranging… CONTINUE READING
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