Decreased brain dopamine cell numbers in human cocaine users

@article{Little2009DecreasedBD,
  title={Decreased brain dopamine cell numbers in human cocaine users},
  author={Karley Y. Little and Eric Ramssen and Ryan M. Welchko and Vitaly Volberg and Courtney J. Roland and B J Cassin},
  journal={Psychiatry Research},
  year={2009},
  volume={168},
  pages={173-180}
}
Cocaine Reduces the Neuronal Population While Upregulating Dopamine D2-Receptor-Expressing Neurons in Brain Reward Regions: Sex-Effects
TLDR
It is observed that cocaine exposed mice had a higher density of D2r-positive cells that was most prominent in mPFC and VTA and larger for females than for males, which could reflect a phenotypic shift in neurons that did not previously express Drd2 and merits further investigation.
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The presented results strongly suggest that cocaine abstinence evokes significant changes in gene expression associated with the proper functioning of glial cells, suggesting their significant involvement in adaptive changes in the brain associated with cocaine exposure.
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TLDR
It is suggested that increased secretion of activin A, particularly from microglia, in the NAc represents a novel potential target for the treatment of cocaine relapse.
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Sleep Disturbance Alters Cocaine-Induced Locomotor Activity: Involvement of Striatal Neuroimmune and Dopamine Signaling
TLDR
It is hypothesized that sleep fragmentation was capable of blunting cocaine-induced psychoactive effects through modulating neuroimmune and dopamine signaling in the brain reward circuitry, which might mediate the linkage between sleep disorders and drug addiction.
Structural plasticity in mesencephalic dopaminergic neurons produced by drugs of abuse: critical role of BDNF and dopamine
TLDR
Encouraging neuroimaging data in humans indirectly support the preclinical evidence of hypotrophic and hypertrophic effects, suggesting a possible differential engagement of dopamine neurons in parallel and partially converging circuits controlling motivation, stress, and emotions.
Region-Specific Reductions in Morphometric Properties and Synaptic Colocalization of Astrocytes Following Cocaine Self-Administration and Extinction
TLDR
An assessment of the effects of cocaine self-administration on morphometric properties and synaptic colocalization of astrocyte peripheral processes in the prelimbic region of the medial prefrontal cortex and basolateral nucleus of the amygdala, both known to also contribute significantly to motivated behaviors are extended.
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Cocaine Uptake Is Decreased in the Brain of Detoxified Cocaine Abusers
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