• DOI:10.1016/j.psychres.2008.10.034
Corpus ID: 27618292

Decreased brain dopamine cell numbers in human cocaine users

@article{Little2009DecreasedBD,
  title={Decreased brain dopamine cell numbers in human cocaine users},
  author={K. Little and Eric Ramssen and Ryan Welchko and Vitaly Volberg and B. Cassin},
  journal={Psychiatry Research},
  year={2009},
  volume={168},
  pages={173-180}
}

K. Little, Eric Ramssen, +2 authors B. Cassin

Published 2009

Medicine

Psychiatry Research

Cocaine use diminishes striatal and midbrain dopamine neuronal components in both post-mortem and in vivo human experiments. The diffuse nature of these declines suggests the possibility that cocaine use might cause a loss of dopamine neurons in humans. Previous rodent studies have not detected cocaine-induced dopamine cell damage. The present experiment involved counting midbrain dopamine neurons utilizing both melanin and tyrosine hydroxylase immunoreactivity. Well-preserved blocks ranging… CONTINUE READING

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