Decreased brain-derived neurotrophic factor depends on amyloid aggregation state in transgenic mouse models of Alzheimer's disease.

@article{Peng2009DecreasedBN,
  title={Decreased brain-derived neurotrophic factor depends on amyloid aggregation state in transgenic mouse models of Alzheimer's disease.},
  author={Shiyong Peng and Diego J. Garzon and Monica Marchese and William C. Klein and Stephen D Ginsberg and Beverly M Francis and Howard T. J. Mount and Elliott J. Mufson and Ahmad Salehi and Margaret Fahnestock},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2009},
  volume={29 29},
  pages={9321-9}
}
Downregulation of brain-derived neurotrophic factor (BDNF) in the cortex occurs early in the progression of Alzheimer's disease (AD). Since BDNF plays a critical role in neuronal survival, synaptic plasticity, and memory, BDNF reduction may contribute to synaptic and cellular loss and memory deficits characteristic of AD. In vitro evidence suggests that amyloid-beta (A beta) contributes to BDNF downregulation in AD, but the specific A beta aggregation state responsible for this downregulation… CONTINUE READING