Decreased brain-derived neurotrophic factor (BDNF)- and β-thromboglobulin (β-TG)- blood levels in Alzheimer's disease

Abstract

Thromb Haemost 2006; 96: 102–3 Dear Sir, What do platelets and their proteins have to do with Alzheimer's disease (AD)? To answer that question, we enrolled patients in the following pilot study. AD is the most common form of dementia in the elderly. Recent findings have suggested an involvement of brain-derived neurotrophic factor (BDNF) and altered platelet functions in the pathogenesis of AD (1, 2). BDNF is an endogenous protein involved in the maintenance of neuronal function, synaptic plasticity and structural integrity in the adult brain. Since platelets are supposed to be an important source of BDNF in the circulation (3), we examined blood levels of BDNF and β-thromboglobulin (β-TG), an established platelet activation marker (4), in AD patients and healthy controls. Twenty-eight AD outpatients from our Memory clinic [11 males and 17 females, mean age 70.4 years, mean Mini-Mental State Examination (MMSE) score of 23.7] and 10 healthy elderly controls (six males and four females, mean age 69.1 years, mean MMSE score of 28.4) were included in the study.All AD patients met the diagnostic criteria of probable AD according to the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-4), the ICD-10 Classification of Mental and Behavioural Disorders (ICD-10) and the criteria of the National Institute of Neurologic and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) (5). The severity of dementia was assessed by MMSE (6). The control subjects were healthy elderly volunteers with normal clinical and cognitive status according to clinical examination and MMSE score. Patients or control subjects with current or a history of depression or psychosis, with neurologic disorders, major physical illness, alcohol or substance abuse or use of psychoactive medications were excluded from the study. The regional ethical committee approved the study and written informed consent was obtained from each individual. Peripheral venous blood was sampled between 8:00 and 9:00 a.m. taking in account a possible circadian rhythm. Serum and plasma were centrifuged within 30 minutes

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Cite this paper

@inproceedings{Laske2017DecreasedBN, title={Decreased brain-derived neurotrophic factor (BDNF)- and β-thromboglobulin (β-TG)- blood levels in Alzheimer's disease}, author={Christoph Laske and Elke Stransky and Thomas Leyhe and Gerhard W. Eschweiler and Klaus Joachim Schott and Harald F Langer and Meinrad Paul Gawaz}, year={2017} }