Decreased bone mineral density in prepubertal children with sickle cell disease: correlation with growth parameters, degree of siderosis and secretion of growth factors.

@article{Soliman1998DecreasedBM,
  title={Decreased bone mineral density in prepubertal children with sickle cell disease: correlation with growth parameters, degree of siderosis and secretion of growth factors.},
  author={Ashraf T. Soliman and Hadia Bererhi and Ahmed M. Z. Darwish and M M Alzalabani and Yasseer Wali and Bijan Ansari},
  journal={Journal of tropical pediatrics},
  year={1998},
  volume={44 4},
  pages={194-8}
}
Patients with sickle cell disease (SCD) frequently have bone disorders of multifactorial aetiology. We attempted to analyse the relationships between bone mineral density (BMD) on the one hand and auxologic parameters, degree of siderosis, function of the growth hormone (GH)/insulin-like growth factor-I (IGF-I)/IGF-binding protein 3 (IGFBP3) axis, and calcium-phosphate balance in 28 prepubertal children with SCD and 15 age-matched children with constitutional short stature (CSS). Children with… CONTINUE READING
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